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April 2015 Issue of The Pathologist

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Articles featured in this issue

Outside the Lab Training and education

Stop the Press!

| Fedra Pavlou

Can negative media reports open up a good opportunity for pathology?

Inside the Lab Oncology

Tumor Only Sequencing Could Be Misleading

| Michael Schubert

Many hospitals sequence patients’ tumor genomes to personalize their treatment – but without sequencing normal tissue, this can harm rather than heal.

Diagnostics Regulation and standards

Hitting the Mark

| Roisin McGuigan

New US guidelines for colorectal cancer testing highlight the importance of molecular markers

Diagnostics Oncology

Buying the Hype

| Michael Schubert

As consumer genetic testing becomes cheaper and easier to access, medical professionals worry that unregulated Internet marketing may steer patients in the wrong direction

Inside the Lab Regulation and standards

Clamping Down on Mistaken Identity

| Fedra Pavlou

Mislabeling and contamination of cell lines in labs are well-known issues, but often nothing is done about them; journal publishers are getting tough

Outside the Lab Microbiology and immunology

In a Swipe of a Swab

| Fedra Pavlou

Researchers believe a simple oral swab test could overcome the limitations of standard sputum testing methods for tuberculosis

Subspecialties Genetics and epigenetics

Cancer’s Common Core

| Michael Schubert

Genetic flaws shared by all metastases of a single prostate cancer may be the key to personalized treatment.

Outside the Lab Point of care testing

Nanoparticle Nephrology

| Michael Schubert

A new device combining nanoparticles with pregnancy testing technology may provide rapid, inexpensive kidney disease diagnosis and monitoring

Outside the Lab Hematology

Celiac Screening

| Roisin McGuigan

Growth monitoring could screen children for celiac disease, enabling easier lab diagnosis

Outside the Lab Genetics and epigenetics

Assemble the MinIONs

| Roisin McGuigan

A pocket-sized DNA sequencer powered by a USB connection could bring disease differentiation capabilities to remote locations

Outside the Lab Oncology

Dubious Diagnoses?

| Michael Schubert

Recent media attention on diagnostic discordance has patients shying away from cancer screening – but are they justified?

Outside the Lab Oncology

Not Reflective of Clinical Practice

| Kenneth Bloom

Although the JAMA article (1) claims to have identified a lack of consistency in pathologists’ breast cancer diagnoses, this doesn’t reflect actual clinical practice

Outside the Lab Regulation and standards

Collaborating on Cancer Care

| Michael Misialek

The major challenge in diagnosing the potential for breast cancer at the premalignant stages lies in recognizing it.

Diagnostics Genetics and epigenetics

A Personalized Reality

| Matthew Smith , George Burghel

Next generation sequencing holds much promise for personalized cancer diagnosis, treatment and management, but how is this being realized and what does the future hold?

Inside the Lab Neurology

NeuroComplexity a Diagnostic Dilemma?

| Roisin McGuigan

Diagnosing neurodegenerative diseases like Alzheimer’s can be a hit and miss process – but is a lab-based test on the horizon?

Diagnostics Biochemistry and molecular biology

Benchmarking Biomarkers of Myocardial Infarction

| Roisin McGuigan

What does analysis of the last five years of literature on myocardial infarction biomarkers tell us about the priorities of this field of research and the major contributors to it?

Outside the Lab Profession

Examining the Entrance to Elysium

| Michael Schubert

The UK FRCPath Part 2 exam is viewed as a problematic stumbling block by many. Why?

Outside the Lab Training and education

Inspiring the Next Generation

| Michael Prystowsky

We sit down with Michael Prystowsky, Professor of Pathology, Montefiore Medical Centre, NY, USA.

Other issues of 2015