December 2015 Issue of The Pathologist

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Over 90 percent of the human cutaneous virome is made up of unclassifiable “dark matter”

A big data approach to cancer driver genes yields insights into how these mutations affect protein interaction

Genetic testing could shed light on unexplained low blood counts

Integrin expression by tumor exosomes could help oncologists pinpoint which patients will present with metastatic disease – and to which organs

αB-crystallin expression could identify breast cancer patients at risk of developing brain metastasis.

Cardiac troponin can be used as an independent early indicator of end-stage kidney disease, and death, new study suggests

An all-plastic microscope for fast staining and analysis of white blood cells could allow cheap, point-of-care blood work

Can we accept meningothelial hyperplasia as a true preneoplastic proliferative?

What is "The Individual Quality Control Plan (IQCP)" and should test sites adopt it?

Pancreatic cancer is tough to understand, diagnose and treat. Undeterred researchers are on a quest to crack the case.

Circulating tumor cells may hold information crucial for better pancreatic cancer diagnosis and treatment – but locating them needs special tactics

Pancreatic cancer is a challenge to stage because there’s no good molecular imaging method – but three new antibody conjugates may change that

Pancreatic cancer is often treated as a homogeneous disease, but new research reveals distinct subtypes of tumor and stromal gene expression

Screening for pancreatic cysts can help with early detection and treatment – but how can we tell which lesions are benign and which may progress to cancer?

Epithelial-to-mesenchymal transition in pancreatic cancer may play a role in treatment resistance.

A new immunotherapy approach shows that engineered T cells are able to penetrate into pancreatic tumors and directly attack the cancer

When genetics yielded unsatisfactory answers about pancreatic cancer’s persistent survival, researchers looked beyond the genome – and found telling epigenetic changes

It’s often difficult to target pancreatic cancer cells while sparing healthy tissue – but a new therapy concept not only makes this possible, but also enhances the potential effectiveness of adjuvant treatments

RNA in situ hybridization offers a new way to overcome the challenges of advancing RNA cancer biomarkers to the clinic

Confocal Raman microscopy is a new, noninvasive way of obtaining morphological and chemical information about cells that may lead to better cancer research

New super-resolution microscopy techniques give us better insight into how our immune cells fight cancer, and how we can help

What does analysis of the last five years of the literature on ALS tell us about the priorities of the field, and the major contributors to it?

UK lab medicine experts team up with their counterparts in Africa to improve testing outcomes.

Considering the impact of the consumer health revolution on pathology

We Sit Down With Michael Wells, Past President of the European Society of Pathology.