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“Welcome to the December issue. Our upfront topics range from an investigation of the “dark virome”, to a 3D printed plastic microscope for quick and inexpensive blood counts. Our Feature looks at the huge challenge pancreatic ductal adenocarcinoma poses and the perseverant researchers on a mission to improve survival rates. In Practice features Raman spectroscopic imaging for powerful cell analysis, and in Next Gen we benchmark amyotrophic lateral sclerosis. In profession, Peter Chimkupete recounts his experiences mentoring African laboratories in order to improve quality standards, and we Sit Down With Michael Wells, Emeritus Professor of Gynecological Pathology, University of Sheffield Medical School, UK, and Past President of the European Society of Pathology.”