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Precision medicine

Inside the Lab Biochemistry and molecular biology

A Fluid Future

| Luke Turner

Liquid biopsy has shown promise as a rapid, minimally invasive way to profile tumors – but are commercially available tests accurate and consistent?

Subspecialties Genetics and epigenetics

Putting a Bug in Your Ear

| Michael Schubert

Variants in the FUT2 gene may increase susceptibility to otitis media by altering the microbiome of the middle ear

Diagnostics Liquid biopsy

A Diagnostic to Drool Over?

| Luke Turner

The use of saliva as a diagnostic fluid seems an attractive option – especially now that research reveals circulating tumor DNA in the fluid

Diagnostics Genetics and epigenetics

Scrutinizing Breast Cancer

| Michael Schubert

The FLEX breast cancer registry intends to collect complete information on 10,000 patients over the course of 10 years

Diagnostics Biochemistry and molecular biology

Treat or Surveil

| George Vasmatzis and John Cheville

Newly discovered genetic alterations could indicate whether treatment or active surveillance is the best option for low-risk prostate cancer patients

Diagnostics Clinical care

MDLUX2: Drawing a Fuller Picture

| Michael Schubert

Luxembourg’s new molecular diagnostics program aims to establish the value of such analyses as a part of routine cancer care

Inside the Lab Liquid biopsy

Building a Better Biopsy

| Lisa M. Wright

To harness liquid biopsy’s many advantages, it’s vital to ensure appropriate testing – and cfDNA synthetic plasma reference standards can help

Inside the Lab Digital and computational pathology

Watch This Space!

| Anant Madabhushi

The spatial arrangement of immune cells could predict whether aggressive chemotherapy is the best option for patients with early-stage lung cancer

Diagnostics Analytical science

An Analytical Pill

| Michael Schubert

An electronic gas-sensing capsule may increase diagnostic and monitoring accuracy in disorders of the digestive tract

Diagnostics Genetics and epigenetics

The Evolution of Epigenetic Biomarkers

| Niamh Buckley, Laura Feeney, James Beirne, and Paul Mullan

Markers such as DNA methylation, analyzed by liquid biopsy, may improve on ovarian cancer testing options like gold standard CA125

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