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December 2014 Issue of The Pathologist

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Articles featured in this issue

Outside the Lab Genetics and epigenetics

Opening the Floodgates

| Fedra Pavlou

The controversial approval of a home-based DNA test kit in the UK raises eyebrows.

Subspecialties Oncology

Global Cancer Study Reveals Shocking Statistics

| Roisin McGuigan

Study of over 25 million people highlights huge geographic differences

Inside the Lab Omics

Non-Invasively Diagnosing Endometriosis

| Roisin McGuigan

Gene expression profiling could reduce endometriosis surgery and increase diagnosis.

Diagnostics Oncology

BRCA Mutations Could Reduce 10-Year Survival by Up to 50 Percent

| Roisin McGuigan

Carriers of BRCA gene mutations appear to be less responsive to conventional prostate cancer therapy

Inside the Lab Histology

Pathology in a Tube

| Roisin McGuigan

Biopsy tissue sample preparation in a tube promises to be cheap, fast, reproducible and automated.

Diagnostics Point of care testing

Diagnosing HIV With No Lab Facilities?

| Roisin McGuigan

Point-of-care molecular diagnosis could make a big difference to disease control in remote communities

Subspecialties Oncology

In Pursuit of Immortality

| Roisin McGuigan

Cell lines that have avoided senescence but kept their normal genome could provide new avenues for cancer research

Diagnostics Genetics and epigenetics

WGS Unravels Idiopathic Epilepsy

| Roisin McGuigan

Potassium regulation appears to be the culprit in three case studies

Outside the Lab Microbiology and immunology

On a Mission to Banish River Blindness

| Roisin McGuigan

A new diagnostic test could help wipe out the neglected disease for good

Outside the Lab Training and education

The Last Respite of the Socially Inept?

| Michael Schubert

Negative stereotypes about pathology are damaging the field – but exactly what are those stereotypes, and how do we defeat them?

Inside the Lab Regulation and standards

The Bottom-Up Approach to Quality Assurance

| Linda Thienpont, Dietmar Stöckl

Lab testing is critical for diagnosis and monitoring - but how do we know tests are fit?

Diagnostics Regulation and standards

Taking On the Challenge of Automating Mitosis Detection

| Humayun Irshad

Two frameworks developed to detect mitosis in color and multispectral histopathology images

Inside the Lab Microbiology and immunology

Stopping Superbugs in Their Tracks

| Michael Schubert

A new biosensor technique takes advantage of bacteriophages to rapidly detect drug-resistant pathogens.

Inside the Lab Digital and computational pathology

Pocket Pathology

| Woei Ming (Steve) Lee

A new method of lens production brings high-quality digital pathology into the realm of the smartphone

Outside the Lab Training and education

Revving Up Reform

| Jane Kirkup

Changes to pathology services are needed now more than ever. Why are they taking so long?

Diagnostics Histology

The Next Gen of Histopathology Training

| Jacqueline James, Manuel Salto Tellez

Are we ready to meet the demands of modern clinical practice?

Outside the Lab Microbiology and immunology

Committed to Improvement, Committed to Change

| Fraser Charlton

Sitting Down With… Fraser Charlton, Consultant Pathologist and Head of Department, Royal Victoria Infirmary, Newcastle Upon Tyne, UK

Subspecialties Hematology

Smart Oxygen Cuvette for Optical Monitoring of Dissolved Oxygen in Biological Blood Samples

| Sponsored by Ocean Optics

A “smart” oxygen cuvette has been developed by coating the inner surface of a plastic (PMMA) cuvette with sol-gel based oxygen-sensitive indicator material.

Other issues of 2014