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Welcome to the November issue. Our Upfront topics range from detecting cancer with carbon, to profile-building initiatives for ALS. Our cover feature speaks with lab champions about efforts to make global changes, and In Practice reviews the value of morphological data, and lab water woes. We discuss Google’s grand genome plans, and examine a new, inexpensive molecular imaging technique in NextGen. Profession highlights the criticality of collaboration, and we Sit Down With immunotherapy pioneer, Robert Pierce.