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Precision medicine

Diagnostics Genetics and epigenetics

Reference Genome Refresh

| Luke Turner

An analysis of 1,000 Swedish genomes reveals greater heterogeneity and shows why the human reference genome needs updating

Diagnostics Genetics and epigenetics

A Pharmacogenomic Promise

| Michael Schubert

Pharmacogenomic testing can only improve patient care if it’s clinically validated, judiciously applied, and easily understood by healthcare providers

Inside the Lab Precision medicine

All the RAGE

| Luke Turner

A new genomic barcode tracker could help spot the rare immune cells that are most effective against cancer

Inside the Lab Biochemistry and molecular biology

Super Method Seeks Cancer's Kryptonite

| Jonathan James

The combination of genome-scale CRISPR experiments and powerful computational approaches has created a Cancer Dependency Map

Inside the Lab Regulation and standards

Wasting the Gift of Life?

| Sumit Mohan

Kidney discard rates are higher than ever – but the procurement biopsies that often rule out their use are unreliable and need to be standardized

Inside the Lab Genetics and epigenetics

Load Versus Response

| Jonathan James

Higher tumor mutational burden is linked to improved survival across multiple cancer types.

Diagnostics Precision medicine

Time, Money, and Tissue

| Jason Ramos

Simultaneous multiplex immunohistochemistry can provide efficient testing of multiple targets when diagnosing and selecting treatment for cancer

Diagnostics Companion diagnostics

Improving Patient Outcomes

| Eslie Dennis, Eric Walk, Ken Bloom, Mark Kockx

A response to David Rimm’s letter that supports the role of PD-L1 testing in improving outcomes for cancer patients.

Diagnostics Companion diagnostics

Welcome to Our Kitchen

| David L. Rimm

David Rimm challenges the sensitivity and reproducibility of a new assay for PD-L1 detection.

Diagnostics Liquid biopsy

Fine-Tuning Immunotherapy

| George Karlin-Neumann

Techniques like droplet digital PCR technology can assist with early monitoring of cancer immunotherapy to ensure the right treatment for each patient

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