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Companion diagnostics

Diagnostics Companion diagnostics

Improving Patient Outcomes

| Eslie Dennis, Eric Walk, Ken Bloom, Mark Kockx

A response to David Rimm’s letter that supports the role of PD-L1 testing in improving outcomes for cancer patients.
Diagnostics Companion diagnostics

Welcome to Our Kitchen

| David L. Rimm

David Rimm challenges the sensitivity and reproducibility of a new assay for PD-L1 detection.
Inside the Lab Companion diagnostics

Fluid Evidence

Liquid biopsy can help us appropriately treat patients with anti-PD-L1 immunotherapies, and ddPCR enables ongoing monitoring and adjustment of treatment
Subspecialties Biochemistry and molecular biology

A Boost for Cervical Cancer Screening

| Liang Cao, Zhigang Kang

An efficient alternative to pap-HPV tests could lie with ddPCR and a ccfDNA assay
Inside the Lab Genetics and epigenetics

A Guiding Light for Molecular Testing

| Antonia R. Sepulveda

New collaborative guidelines for molecular biomarker testing in colorectal cancer
Diagnostics Regulation and standards

Seeking the Killer App

| David Rimm

An examination of domain-specific companion diagnostic testing
Outside the Lab Profession

Inside Industry

| Bharathi Vennapusa

An industry pathologist’s perspective on developing a companion diagnostic
Outside the Lab Quality assurance and quality control

A Blueprint for the Future

| Henrik Winther and Hans Christian Pedersen

Industry and regulators collaborate to harmonize or consolidate PD-1/PDL-1 assays
Outside the Lab Profession

Liquid Biopsy and NGS: Teaming Up to Take Cancer Apart

| Nicola Normanno, Jose Machado

How liquid biopsy and next-generation sequencing fit into the pathology lab of the future
Diagnostics Profession

Marker of Excellence

| Fedra Pavlou

Anthony Whetton, Director of the Stoller Biomarker Discovery Centre, Manchester, UK
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