Cookies

Like most websites The Pathologist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Inside the Lab Companion diagnostics, Microbiology and immunology, Laboratory management, Oncology, Liquid biopsy, Precision medicine, Technology and innovation

Fluid Evidence

Of the more than 200 different types of cancer we have identified, those that affect the skin and lung are among the most common. Together, they represent about one-fifth of all new cancer diagnoses (1)(2)(3)(4). Immune checkpoint inhibitors, drugs that boost the body’s T-cell anti-tumor response by removing the brakes that typically prevent the immune system from killing tumor cells, have greatly improved clinical outcomes for patients with melanoma and non-small cell lung cancer (NSCLC). One commonly targeted molecular brake is programmed cell death protein-1 (PD-1), a receptor found on the surface of T cells. By preventing PD-1 from binding to its target on cancer cells, programmed death ligand-1 (PD-L1) allows T cells to attack the tumor – which is why anti-PD-1 antibodies, such as pembrolizumab and nivolumab, are now approved first-line therapies for patients with advanced melanoma and NSCLC (5)(6). Clinical pathologists measure the expression of PD-L1 in tumor tissue to identify patients who score high for PD-L1 expression and therefore might derive the most benefit from immunotherapy.

Read the full article now

Log in or register to read this article in full and gain access to The Pathologist’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

Register to The Pathologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine

Register