Subscribe to Newsletter
Subspecialties Microbiology and immunology

Functional Consequences

Researchers behind a US-based study focused on women with HIV have found that epigenetic aging is accelerated compared with women without HIV (1).

Using Infinium BeadChips, the team measured DNA methylation age in 190 participants, alongside bone mineral density and physical function assessments. The results confirmed that measures of accelerated epigenetic aging are associated with lower physical function. But no significant associations were found between accelerated epigenetic aging and bone mineral density, despite links being established in a previous study (2).

“We were surprised to find no relationship between accelerated aging and bone mineral density,” says lead author Stephanie Shiau, “Ongoing research is needed to progress our understanding of these results.”

“Alongside exploring accelerated aging at different stages across the lifespan, we’re also hoping to investigate what factors may be related to lessened or increased accelerated aging, such as antiretroviral therapy,” continues Shiau. “Deepening our understanding of how aging, HIV infection, treatment, and comorbidities interact with each other is key in maintaining health and quality of life for people living with HIV.”


The Pathologist Presents:

The Pathologist Weekly Newsletter

Enjoying yourself? There's plenty more where that came from! Our weekly Newsletter brings you the most popular stories as they unfold, chosen by our fantastic Editorial team!

Register for our weekly newsletter

Credit: Images for collage sourced from Pexels and

Receive content, products, events as well as relevant industry updates from The Pathologist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. S Shiau et al., J Infect Dis, (2024). PMID: 38366369.
  2. A Sharma et al., Clin Infect Dis, 75, 1, (2022). PMID: 34595517.
About the Author
Jessica Allerton

Deputy Editor, The Pathologist

Register to The Pathologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine