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Diagnostics Analytical science, Microbiology and immunology

Evaluating Technical Proficiency of ADRA Skin Sensitization Testing and High Speed Analysis

Skin sensitization tests evaluate the allergic reactivity of skin to chemical substances. For animal welfare reasons, non-animal alternative methods are being developed for these tests. Chemical substances can induce an inflammatory reaction if they bind to cysteine or lysine in epidermal proteins. International test guidelines for evaluating chemical substances, published by the Organisation for Economic Co-operation and Development (OECD), include the Direct Peptide Reactivity Assay (DPRA) and Amino Acid Derivative Reactivity Assay (ADRA) as alternative in chemico test methods based on the properties indicated above.

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