Genetics and epigenetics

It’s tricky to distinguish between valid and false-positive miRNA biomarkers – but evolutionarily conserved genetic signatures in animals could help

The combination of genome-scale CRISPR experiments and powerful computational approaches has created a Cancer Dependency Map

Higher tumor mutational burden is linked to improved survival across multiple cancer types.

Combining metabolomics and DNA sequencing could be the key to discovering new inborn errors of metabolism in children.

Genomic research has a diversity problem that could restrict the future effectiveness of precision medicine for minority groups

New guidelines for CYPC29 genotyping ensure that the correct alleles are tested and patients are prescribed the correct doses of common drugs

We speak to bioengineer Stephen Quake to learn about the noninvasive prenatal tests that have saved thousands of pregnant women’s lives

Triple-negative breast cancer is not a single entity, and understanding each patient’s molecular subtype can influence treatment and outcomes

The move to in-house next-generation sequencing has resulted in time and tissue savings, and improved collaboration across cancer care specialties

A new detection method enhances circular RNA’s potential as a cancer biomarker and forms the basis of a new database