The Right Dose for the Right Person
CYPC29 genotyping guidelines can help labs ensure that patients receive the correct dose of commonly prescribed drugs
Michael Schubert | | Quick Read
Warfarin – the most widely used anticoagulant in the world, it’s a well-known drug even amongst non-experts. Phenytoin, an anticonvulsant, is also among the most commonly prescribed drugs in its class. But despite their ubiquity, it can be difficult to establish the minimal effective dose for a patient. This is especially true in situations where their genotypes might be affecting metabolism of the drug – for instance, in patients who exhibit mutations in genes coding for the cytochrome P450 enzyme CYP2C9.
For this reason, the Association for Molecular Pathology (AMP) Pharmacogenetics Working Group has developed a series of guidelines to help standardize clinical testing for these genes (1). The AMP-led working group included organizational representation from both the College of American Pathologists and the Clinical Pharmacogenetics Implementation Consortium (CPIC). To learn more, we spoke to Victoria M. Pratt, Associate Professor and Director of Pharmacogenetics and Molecular Genetics Laboratories at the Indiana University School of Medicine, AMP President, and PGx Working Group Chair.
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