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Genetics and epigenetics

Subspecialties Oncology

Kill Command for Cancer

| Luke Turner

Naturally occurring miRNA sequences can be deadly to cancer cells, but can this be ramped up to maximize toxicity?

Diagnostics Genetics and epigenetics

The Evolution of Epigenetic Biomarkers

| Niamh Buckley, Laura Feeney, James Beirne, and Paul Mullan

Markers such as DNA methylation, analyzed by liquid biopsy, may improve on ovarian cancer testing options like gold standard CA125

Subspecialties Analytical science

A Lasting Legacy

| Mary J. Wirth

A story of war, famine, epigenetics, and how all three colluded to change the phenotype of a generation of babies – and beyond

Diagnostics Genetics and epigenetics

Thinking Outside the (Genome) Box

| Jason Mellad

Epigenetics may combine with liquid biopsy to offer an effective way of detecting early-stage cancers and recurrences

Outside the Lab Genetics and epigenetics

A Global Citizen

We sit down with Malak Abedalthagafi to talk about the biggest issues facing pathology and how she has adapted to working around the globe

Inside the Lab Clinical care

Biochip Breakthrough

| Luke Turner, Arjang Hassibi

With antimicrobial resistance an ever-increasing threat to modern medicine, a new breakthrough may rapidly identify drug-resistant microbe strains to ensure effective treatment

Inside the Lab Biochemistry and molecular biology

One Drop at a Time

| Alexander Dobrovic and Cloud Paweletz

When seeking the greatest benefit from liquid biopsy, droplet digital PCR can help by offering speed, sensitivity, and absolute quantitation

Outside the Lab Biochemistry and molecular biology

Pre-Empting Relapse

| Luke Turner

A new DNA test that can detect treatment-resistant mutations could prove crucial for patients with acute myeloid leukemia, providing an early indication that targeted therapeutic intervention is needed

Outside the Lab Genetics and epigenetics

From Bench to Bedside and Back Again

| Roisin McGuigan

Sitting Down With James Wilson, Rose H. Weiss Professor and Director, Orphan Disease Centre, Profession of Medicine and Pediatrics, University of Pennsylvania

Diagnostics Cytology

What’s in a Brain?

| Jason Karamchandani

Jason Karamchandani explains how anatomic pathologists can identify and distinguish between the most common intracranial neoplasms of adulthood

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