Specific Detection of Inflammation Markers with Tissue Context Using RNAscope® Technology

contributed by ACD | 06/15/2015

Detection of Immune Biomarkers in the Tissue

Understanding molecular mechanisms is critical for identifying pathogenesis, evaluating disease progression and developing new therapeutic strategies for autoimmunity, infectious diseases, and cancer. RNAscope^® in situ hybridization (ISH) technology enables precise cell- and tissue-specific localization of RNA transcripts. With RNAscope^® ISH assays, you can detect specifically expressed immune markers in lymphoid and non-lymphoid tissues while maintaining the morphological context. For example, RNAscope^® chromogenic in situ hybridization (CISH) robustly identified the expression pattern of CD274 mRNA in formalin-fixed paraffin-embedded (FFPE) kidney cancer tissue (Figure 1).

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