A new tool could predict whether cancer patients will benefit from immunotherapy
Luke Turner | | Quick Read
Nonsense mutations in the DNA disrupt protein synthesis and can lead to hereditary diseases and cancer. The human immune system generally recognizes and remove these nonsense mutations in a process called nonsense-mediated mRNA decay (NMD) – but new research shows that NMD can actually result in greater disease severity, especially in cancer patients, where NMD may prevent tumor cells from being exposed to the immune system (1).
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