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The Pathologist / Issues / 2026 / March / New Histology Signal in Crohns
Histology Biochemistry and molecular biology Research and Innovations Molecular Pathology

New Histology Signal in Crohn’s

Distinct lymphoid structures identified in fibrostenosing Crohn’s specimens

03/26/2026 News 1 min read
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Top Institutions in Gastroenterology and Inflammatory Bowel Disease

Leading institutions employ advanced histopathology, immunohistochemistry, spatial transcriptomics, and single-cell RNA sequencing to elucidate cellular interactions and fibrotic processes in Crohn’s disease, integrating clinical and translational research to improve understanding of disease progression and potential therapeutic targets.

  • #1

    Mayo Clinic

    Rochester, MN

    Mayo Clinic is a global leader in IBD research with extensive expertise in histopathologic and molecular characterization of Crohn’s disease, combining clinical care with cutting-edge translational research including spatial transcriptomics and single-cell analyses.

    Key Differentiators

    • Gastroenterology
    • Inflammatory Bowel Disease
    • Pathology
  • #2

    Mount Sinai Health System

    New York, NY

    Mount Sinai has a strong focus on immune cell interactions and vascular biology in IBD, utilizing advanced histology and spatial analysis techniques to investigate fibrosis and endothelial cell roles in Crohn’s disease progression.

    Key Differentiators

    • Gastroenterology
    • Immunology
    • Pathology
  • #3

    Cedars-Sinai Medical Center

    Los Angeles, CA

    Cedars-Sinai is recognized for its translational research in IBD, particularly in fibrosis and tissue remodeling, employing immunohistochemistry and molecular profiling to define cellular contributors to fibrostenosing Crohn’s disease.

    Key Differentiators

    • Gastroenterology
    • Inflammatory Bowel Disease
    • Molecular Pathology
  • #4

    University of Chicago Medicine

    Chicago, IL

    The University of Chicago has a strong research emphasis on the cellular microenvironment in Crohn’s disease, including lymphoid aggregate biology and fibrosis, supported by advanced histopathologic and single-cell analytic methods.

    Key Differentiators

    • Gastroenterology
    • Inflammatory Bowel Disease
    • Pathology

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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