Objective:

To investigate the association between endothelial cell clusters and submucosal scarring in fibrostenosing Crohn’s disease.

Key Findings:

• Endothelial cell clusters were identified within or adjacent to lymphoid aggregates.
• These clusters were distinct from surrounding blood vessels.
• Lymphoid aggregates with endothelial clusters were more frequently located near areas of submucosal fibrosis.
• Higher fibrosis scores were associated with endothelial-containing aggregates.

Interpretation:

The presence of endothelial clusters alongside fibrosis indicates a potential interaction between immune organization, vascular changes, and tissue remodeling in fibrostenosing Crohn’s disease.

Limitations:

Conclusion:

Identification of lymphoid aggregates with endothelial clusters may enhance the evaluation of specimens from patients with suspected fibrostenosing Crohn’s disease.