5 Key Takeaways

• 1

  Endothelial cell clusters are associated with submucosal scarring in fibrostenosing Crohn’s disease.

• 2

  Fibrostenosing Crohn’s disease is characterized by bowel wall thickening and narrowing of the gut lumen.

• 3

  Lymphoid aggregates containing endothelial clusters are linked to higher fibrosis scores in adjacent tissue.

• 4

  Spatial analysis revealed that endothelial clusters are more frequently near areas of submucosal fibrosis.

• 5

  Identifying lymphoid aggregates with endothelial clusters may enhance evaluation of fibrostenosing Crohn’s disease.