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The Pathologist / Issues / 2026 / January / What Causes Metastasis in Deadly Eye Cancer
Oncology Biochemistry and molecular biology Omics Research and Innovations Molecular Pathology

What Causes Metastasis in Deadly Eye Cancer?

Gene expression profiling sheds new light on malignant transformation in uveal melanoma

01/12/2026 News 3 min read
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Top Institutions in Ocular Oncology and Molecular Oncology

Leading institutions employ integrated molecular diagnostics including next-generation sequencing and gene expression profiling to study tumor biology, prognosticate metastatic risk, and guide clinical management of uveal melanoma.

  • #1

    Wills Eye Hospital, Thomas Jefferson University

    Philadelphia, PA

    Wills Eye Hospital is a world leader in ocular oncology with a dedicated uveal melanoma program that integrates clinical care with advanced molecular diagnostics and participates in multicenter studies such as the Collaborative Ocular Oncology Group.

    Key Differentiators

    • Ocular Oncology
    • Molecular Pathology
    • Ophthalmology
  • #2

    Memorial Sloan Kettering Cancer Center

    New York, NY

    MSKCC has a strong ocular oncology service and is recognized for its research in cancer genomics and molecular profiling, contributing to understanding metastatic mechanisms in uveal melanoma.

    Key Differentiators

    • Medical Oncology
    • Ocular Oncology
    • Cancer Genomics
  • #3

    Bascom Palmer Eye Institute, University of Miami

    Miami, FL

    Bascom Palmer is internationally recognized for its clinical and research expertise in ocular tumors, including pioneering work in gene expression profiling and molecular characterization of uveal melanoma.

    Key Differentiators

    • Ophthalmology
    • Ocular Oncology
    • Molecular Diagnostics
  • #4

    National Eye Institute (NEI), NIH

    Bethesda, MD

    NEI conducts foundational research on ocular cancers including uveal melanoma, focusing on molecular mechanisms of tumor progression and metastasis with strong translational research programs.

    Key Differentiators

    • Ocular Research
    • Molecular Oncology
    • Genetics
  • #5

    University of California, San Francisco (UCSF) Medical Center

    San Francisco, CA

    UCSF has a robust ocular oncology program with expertise in molecular genetics and gene expression profiling, contributing to clinical trials and translational research in uveal melanoma.

    Key Differentiators

    • Ocular Oncology
    • Cancer Genomics
    • Ophthalmology

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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