5 Key Takeaways

• 1

  Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a high risk of metastatic death despite local control.

• 2

  A multicenter study highlights gene expression profiling as superior to mutation analysis for risk stratification in UM.

• 3

  Mutations in BAP1, SF3B1, and EIF1AX correlate with high, intermediate, and low metastatic risk, respectively.

• 4

  Small tumors are often low-risk and may represent early evolutionary stages before full malignant transformation.

• 5

  The study emphasizes the importance of integrated molecular testing to differentiate between indolent and aggressive UM lesions.