4 Topic Commentaries

Synthetic DNA Expands the Genetic Alphabet

Synthetic DNA Expands the Genetic Alphabet

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  Floyd E. Romesberg, PhD

  Chemical biology; synthetic biology; nucleic acid chemistry

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  The Scripps Research Institute (TSRI)

  We can now get the light of life to stay on,

  Source
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  Denis A. Malyshev, PhD

  Nucleic acid chemistry; genetic alphabet expansion

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  The Scripps Research Institute (TSRI)

  That was a big breakthrough for us—an enabling breakthrough,

  Source
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  Dong Wang, PhD

  Chemical biology; transcription mechanisms; synthetic biology

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  University of California San Diego

  Considering how diverse life on Earth is with just four nucleotides, the possibilities of what could happen if we can add more are enticing,

  Source
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  Steven A. Benner, PhD

  Synthetic biology; artificial genetic systems; chemical evolution

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  University of Florida

  DNA polymerases have evolved for billions of years to accept the four natural letters in DNA — A, T, C and G,

  Source