5 Key Takeaways

• 1

  Diagnostic Orchestrator (DxO) uses large language models to ask questions, request tests, and refine diagnoses as evidence emerges.

• 2

  In 304 clinicopathological cases, DxO achieved 83% diagnostic accuracy, compared with 36% among physicians with reference materials.

• 3

  In 325 emergency department encounters, DxO achieved 80% accuracy, compared with 47% among physicians.

• 4

  For clinicopathological cases, DxO achieved 81% accuracy at an estimated testing cost of $2,241, versus $4,725 for physicians achieving 36% accuracy.

• 5

  The evaluation used controlled, text-based cases and estimated testing costs, excluding factors such as imaging, pathology slides, incomplete records, and multidisciplinary decisions.