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The Pathologist / Issues / 2026 / May / The Chronic Disease Conundrum
Oncology Biochemistry and molecular biology Clinical care Insights Screening and monitoring

The Chronic Disease Conundrum

Russ Lebovitz and Arnon Chait on why we need smarter biomarkers to guide clinically actionable diagnostics in an aging population

By Jessica Allerton 05/14/2026 Discussion 4 min read
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5 Key Takeaways
  • 1

    Current diagnostic approaches for chronic diseases are limited, particularly in identifying early-stage biomarkers.

  • 2

    A shift towards structured diagnostic pathways could enhance early detection and cost-effective patient care.

  • 3

    Emerging diagnostic methods aim to improve specificity by detecting disease-specific protein changes rather than general abnormalities.

  • 4

    Diagnostics play a critical role in clinical decision-making, yet only a small portion of healthcare spending is allocated to them.

  • 5

    Clinically actionable diagnostics must provide disease-specific insights to guide treatment decisions and improve patient outcomes.

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Jessica Allerton

Deputy Editor, The Pathologist

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