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The Pathologist / Issues / 2026 / March / Targeted NGS Streamlines Myeloproliferative Neoplasm Diagnostics
Oncology Precision medicine Omics Laboratory management Technology and innovation Insights Molecular Pathology Voices in the Community

Targeted NGS Streamlines Myeloproliferative Neoplasm Diagnostics

Kritika Krishnamurthy shares real-world experience on advanced MPN genomic profiling

03/18/2026 Future 7 min read

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Top Institutions in Hematology/Oncology

Leading institutions in hematology and oncology have pioneered the use of NGS panels combined with PCR for comprehensive molecular profiling of MPNs. Their expertise includes clinical trials, genomic research, and guideline development, enabling advanced diagnostic algorithms and personalized treatment strategies.

  • #100

    Dana-Farber Cancer Institute

    Boston, MA

    Dana-Farber is a leader in hematologic malignancies research, with extensive programs in molecular diagnostics and targeted therapies for MPNs, contributing to NCCN guideline development and clinical trials utilizing NGS.

    Key Differentiators

    • Hematology
    • Oncology
    • Genomic Medicine
  • #92

    MD Anderson Cancer Center

    Houston, TX

    MD Anderson has a robust hematologic malignancy program with a focus on molecular characterization of MPNs using NGS and PCR, advancing personalized medicine approaches and developing diagnostic algorithms.

    Key Differentiators

    • Hematology
    • Oncology
    • Molecular Diagnostics
  • #88

    Mayo Clinic

    Rochester, MN

    Mayo Clinic is recognized for its clinical expertise and research in MPNs, particularly in molecular diagnostics integrating NGS and PCR, and for developing diagnostic algorithms that improve detection of low-level variants.

    Key Differentiators

    • Hematology
    • Oncology
    • Molecular Pathology
  • #85

    Memorial Sloan Kettering Cancer Center

    New York, NY

    MSKCC has a strong focus on genomic medicine and hematologic malignancies, utilizing advanced NGS technologies to refine MPN diagnostics and guide targeted therapeutic strategies.

    Key Differentiators

    • Hematology
    • Oncology
    • Genomic Medicine

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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References

  1. Khoury, J.D., Solary, E., Abla, O. et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia 36, 1703–1719 (2022). https://doi.org/10.1038/s41375-022-01613-1
  2. RH Zulkeflee et al., “Clinical and laboratory features of JAK2 V617F, CALR, and MPL mutations in Malaysian patients with classical myeloproliferative neoplasm (MPN),” Int J Environ Res Public Health, 18, 14 (2021). PMID: 34300032.
  3. National Comprehensive Cancer Network, “NCCN guidelines: myeloproliferative neoplasms” (2026). Available at: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1477.
  4. X Liu et al., “A comparison of sequential polymerase chain reaction–based cascade testing vs next-generation sequencing in molecular profiling of myeloproliferative neoplasms: improving testing strategies in light of evolving molecular landscapes,” Lab Med, 56, 5 (2025). PMID: 40238187.

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