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The Pathologist / Issues / 2026 / March / It's Like PCR, But Better
Genetics and epigenetics Liquid biopsy Omics Screening and monitoring Molecular Pathology

It's Like PCR, But Better

Geoff Smith introduces the mcPCR method for methylated DNA analysis that is expanding the potential of epigenetics for disease detection

By Helen Bristow 03/31/2026 Interview 3 min read
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Top Institutions in Molecular Pathology and Epigenetics

Leading institutions in molecular pathology and epigenetics have pioneered research in DNA methylation analysis, PCR technology, and cancer biomarker development, integrating advanced molecular techniques with clinical applications for early disease detection and monitoring.

  • #1

    Dana-Farber Cancer Institute

    Boston, MA

    Dana-Farber is a leader in cancer epigenetics research and clinical translation, with extensive programs in DNA methylation biomarkers and advanced molecular diagnostics for cancer detection and monitoring.

    Key Differentiators

    • Molecular Pathology
    • Cancer Epigenetics
    • Biomarker Development
  • #2

    Johns Hopkins University School of Medicine

    Baltimore, MD

    Johns Hopkins has a strong history in molecular diagnostics and epigenetic research, particularly in developing sensitive assays for methylation detection and applying them to cancer and chronic disease monitoring.

    Key Differentiators

    • Molecular Biology
    • Epigenetics
    • Cancer Diagnostics
  • #3

    Stanford University School of Medicine

    Stanford, CA

    Stanford excels in integrating cutting-edge molecular technologies with clinical research, including novel PCR methods for epigenetic analysis and multi-omic approaches to disease detection.

    Key Differentiators

    • Molecular Pathology
    • Epigenomics
    • Translational Medicine
  • #4

    University of California, San Francisco (UCSF)

    San Francisco, CA

    UCSF is recognized for its research in cancer epigenetics and development of molecular diagnostic tools, including methylation-based assays for early detection and monitoring of malignancies.

    Key Differentiators

    • Cancer Biology
    • Epigenetics
    • Molecular Diagnostics
  • #5

    Memorial Sloan Kettering Cancer Center

    New York, NY

    Memorial Sloan Kettering leads in precision oncology with strong programs in epigenetic biomarker discovery and application of molecular diagnostics for cancer detection and treatment monitoring.

    Key Differentiators

    • Cancer Epigenetics
    • Molecular Diagnostics
    • Precision Oncology

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Helen Bristow

Combining my dual backgrounds in science and communications to bring you compelling content in your speciality.

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