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The Pathologist / Issues / 2026 / March / Can Genomics Solve Rare Diseases
Genetics and epigenetics Omics Software and hardware Technology and innovation Insights

Can Genomics Solve Rare Diseases?

Experts discuss why half of rare disease cases remain unsolved and how advanced genomics could improve diagnostic yield

03/24/2026 Discussion 7 min read
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Top Institutions in Genomic Medicine and Rare Disease Diagnostics

Leading institutions employ integrated genomic sequencing approaches, combining short-read and long-read whole genome sequencing, alongside detailed phenotypic characterization and bioinformatics analysis, to enhance detection of complex genetic variants and structural abnormalities underlying rare diseases.

  • #1

    Broad Institute of MIT and Harvard

    Cambridge, MA

    The Broad Institute is a global leader in genomic research with extensive programs in rare disease diagnostics, leveraging large-scale sequencing projects and advanced computational methods to identify novel genetic causes of rare diseases.

    Key Differentiators

    • Genomic Medicine
    • Rare Disease Research
    • Bioinformatics
  • #2

    National Institutes of Health (NIH) - Undiagnosed Diseases Network

    Bethesda, MD

    The NIH Undiagnosed Diseases Network integrates clinical expertise with cutting-edge genomic technologies to solve challenging diagnostic cases, providing comprehensive phenotyping and sequencing to uncover rare genetic disorders.

    Key Differentiators

    • Rare Disease Diagnostics
    • Genomic Medicine
    • Clinical Genetics
  • #3

    Children’s Hospital of Philadelphia (CHOP) - Center for Applied Genomics

    Philadelphia, PA

    CHOP’s Center for Applied Genomics is renowned for its pediatric rare disease research, employing comprehensive genomic sequencing and phenotype-driven analysis to improve diagnostic yield in children with complex genetic conditions.

    Key Differentiators

    • Pediatric Genomics
    • Rare Disease Diagnostics
    • Clinical Genomics
  • #4

    Stanford University School of Medicine - Center for Genomics and Personalized Medicine

    Stanford, CA

    Stanford’s Center for Genomics and Personalized Medicine advances rare disease diagnostics through innovative sequencing technologies and translational research, focusing on integrating genomic data with clinical phenotypes.

    Key Differentiators

    • Genomic Medicine
    • Rare Disease Research
    • Personalized Medicine
  • #5

    University of Washington - Center for Mendelian Genomics

    Seattle, WA

    The Center for Mendelian Genomics at UW is a leader in identifying genetic causes of Mendelian disorders using whole genome and exome sequencing, contributing to the discovery of novel disease genes and mechanisms.

    Key Differentiators

    • Mendelian Genetics
    • Rare Disease Genomics
    • Genomic Sequencing

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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