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The Pathologist / Issues / 2026 / March / AISelected Trial Candidates are More Diverse
Bioinformatics Research and Innovations

AI-Selected Trial Candidates are More Diverse

Could artificial intelligence-enabled medical chart review improve the speed, accuracy, and equity of study enrollment?

03/10/2026 News 2 min read
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Clinical Scorecard: AI-Selected Trial Candidates are More Diverse

At a Glance

CategoryDetail
ConditionTransthyretin amyloid cardiomyopathy
Key MechanismsAI-enabled platform automating chart review for clinical trial eligibility
Target PopulationPatients with amyloid-related diagnostic codes
Care SettingLarge health system

Key Highlights

  • AI system processed 1,476 patient records in six days
  • Achieved 96.2% accuracy in answering trial-relevant questions
  • Identified 30 eligible patients, 37% of whom were Black
  • 93% of AI-identified patients were not registered with a cardiologist
  • 99% accuracy in excluding ineligible patients

Guideline-Based Recommendations

Diagnosis

  • Utilize AI to analyze EMRs for identifying eligible patients

Management

  • Implement AI systems to streamline clinical trial recruitment processes

Monitoring & Follow-up

  • Regularly assess AI performance against traditional methods

Risks

  • Ensure AI systems are validated for accuracy and reliability

Patient & Prescribing Data

Patients with transthyretin amyloid cardiomyopathy

AI may enhance recruitment from under-represented populations

Clinical Best Practices

  • Integrate AI systems for efficient patient identification
  • Provide traceable explanations for AI decisions
  • Validate AI findings with clinician review

References

  • Journal of Cardiac Failure

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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