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The Pathologist / Issues / 2026 / January / When Thyroid and Parathyroid Collide
Histology Biochemistry and molecular biology Microscopy and imaging

When Thyroid and Parathyroid Collide

Pathologists report the first case of papillary thyroid carcinoma invading an intrathyroidal parathyroid adenoma

By Jessica Allerton 01/26/2026 News 3 min read
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5 Key Takeaways
  • 1

    A rare case of intrathyroidal parathyroid adenoma coexisting with papillary thyroid carcinoma was reported, highlighting diagnostic challenges.

  • 2

    This case is the first documented instance of papillary thyroid carcinoma invading an intrathyroidal parathyroid adenoma.

  • 3

    Intrathyroidal parathyroid adenomas account for less than 6% of primary hyperparathyroidism cases and can mimic benign thyroid nodules.

  • 4

    Fine-needle aspiration biopsy may misidentify parathyroid adenomas as thyroid lesions, complicating preoperative diagnosis.

  • 5

    Thorough histologic examination of thyroidectomy specimens is crucial, as parathyroid adenomas do not exclude concurrent thyroid malignancy.

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Jessica Allerton

Deputy Editor, The Pathologist

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