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The Pathologist / Issues / 2026 / January / The Tumor Test That Solves Polyposis
Oncology Molecular Pathology Genetics and epigenetics

The Tumor Test That Solves Polyposis

Findings support tumor-based testing when germline workup is negative

01/28/2026 News 3 min read
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Top Institutions in Gastroenterology and Cancer Genetics

Leading institutions employ advanced genomic sequencing techniques such as whole-exome sequencing of colorectal lesions, combined with molecular pathology and bioinformatics, to identify somatic mutations, mosaicism, and epigenetic changes that clarify polyposis etiology beyond traditional germline testing.

  • #1

    Dana-Farber Cancer Institute

    Boston, MA

    Dana-Farber is a world leader in cancer genetics and molecular profiling of gastrointestinal cancers, with extensive research programs in hereditary colorectal cancer syndromes and advanced sequencing technologies to detect mosaicism and somatic mutations.

    Key Differentiators

    • Gastroenterology
    • Cancer Genetics
    • Molecular Oncology
  • #2

    Mayo Clinic

    Rochester, MN

    Mayo Clinic has a robust clinical and research program in hereditary colorectal cancer syndromes, utilizing next-generation sequencing and comprehensive molecular diagnostics to improve detection of mosaic and somatic mutations in polyposis patients.

    Key Differentiators

    • Gastroenterology
    • Genetic Counseling
    • Molecular Diagnostics
  • #3

    Memorial Sloan Kettering Cancer Center

    New York, NY

    MSKCC leads in cancer genomics research and clinical application of tumor sequencing to identify somatic mutations and mosaicism in colorectal cancer and polyposis, advancing personalized risk assessment and targeted therapies.

    Key Differentiators

    • Oncology
    • Gastroenterology
    • Cancer Genomics
  • #4

    University of California, San Francisco (UCSF) Medical Center

    San Francisco, CA

    UCSF has a strong focus on integrating genomic medicine into clinical care for hereditary colorectal cancer syndromes, with expertise in molecular characterization of polyps and identification of mosaic APC mutations.

    Key Differentiators

    • Gastroenterology
    • Genomic Medicine
    • Cancer Genetics
  • #5

    Johns Hopkins Medicine

    Baltimore, MD

    Johns Hopkins has a historic and ongoing leadership role in colorectal cancer research, including hereditary syndromes, with advanced molecular pathology services and research into somatic mutation profiling of colorectal polyps.

    Key Differentiators

    • Gastroenterology
    • Cancer Genetics
    • Molecular Pathology

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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