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The Pathologist / Issues / 2026 / January / Could Stool Enzyme Activity Signal IBD
Histology Biochemistry and molecular biology

Could Stool Enzyme Activity Signal IBD?

This chemiluminescence test detects active granzyme A, not just protein levels, in stool samples

01/29/2026 News 2 min read
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Top Institutions in Gastroenterology and Inflammatory Bowel Disease (IBD) Research

Leading institutions combine clinical gastroenterology expertise with translational immunology and bioengineering to develop and validate innovative diagnostic assays, including enzyme activity-based stool tests, supported by large patient cohorts and advanced molecular techniques.

  • #1

    Mayo Clinic

    Rochester, MN

    Mayo Clinic is a global leader in IBD research with extensive clinical trials and translational research programs focused on novel biomarkers and immune mechanisms in IBD. Their integrated approach combines clinical expertise with advanced assay development.

    Key Differentiators

    • Gastroenterology
    • Immunology
    • Biomedical Engineering
  • #2

    Mount Sinai Health System

    New York, NY

    Mount Sinai has a strong focus on immunopathogenesis of IBD and development of novel diagnostic assays, including stool-based biomarkers, supported by collaborations between clinical and engineering departments.

    Key Differentiators

    • Gastroenterology
    • Immunology
    • Biomedical Engineering
  • #3

    University of California, San Diego (UCSD)

    San Diego, CA

    UCSD is recognized for pioneering work in gut immunology and biomarker development, including enzyme activity assays and chemiluminescence technologies for IBD monitoring.

    Key Differentiators

    • Gastroenterology
    • Immunology
    • Biomedical Engineering
  • #4

    Cleveland Clinic

    Cleveland, OH

    Cleveland Clinic has a robust IBD program with emphasis on biomarker research and clinical trials evaluating novel diagnostic tools for disease monitoring and personalized therapy.

    Key Differentiators

    • Gastroenterology
    • Immunology
  • #5

    Massachusetts General Hospital (MGH)

    Boston, MA

    MGH combines clinical gastroenterology with cutting-edge immunology and bioengineering research, contributing to biomarker discovery and validation in IBD, including enzyme activity-based assays.

    Key Differentiators

    • Gastroenterology
    • Immunology
    • Biomedical Engineering

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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