Objective:

To investigate genetic mutations in domestic cats with cancer and their relevance to human cancer.

Key Findings:

• Identified 31 likely driver genes, viral sequences, mutational signatures, and inherited variants linked to cancer risk.
• TP53 was the most frequently mutated gene across tumor types.
• Recurrent copy number changes included loss of PTEN or FAS and gain of MYC.
• Mammary carcinoma in cats showed strong overlap with human breast cancer, particularly with alterations in FBXW7 and PIK3CA.
• Certain chemotherapies were more effective in tumors with FBXW7 alterations.

Interpretation:

Feline cancer exhibits significant genetic parallels with human cancer, suggesting that cats can serve as a valuable model for understanding cancer biology and developing therapies.

Limitations:

• Study focused on a limited number of feline cancer types.
• Further research needed to validate findings and explore therapeutic implications.

Conclusion:

The research establishes a genomic reference for feline cancers and supports the potential for clinical trials in cats to inform human oncology.