Clinical Scorecard: How to Increase Efficiency in Routine Oncology NGS Workflows

At a Glance

Key Highlights

• Amplicon-based NGS (Oncomine Dx Express Test) demonstrated significant efficiency gains over hybrid-capture workflows.
• Turnaround time reduced by 62 hours with the Oncomine Dx Express Test.
• Automation reduces hands-on time from 451 minutes in hybrid-capture to 41 minutes in amplicon-based testing.
• Laboratories face operational challenges due to complex workflows and resource constraints.
• Redesigning workflows can eliminate bottlenecks without compromising quality.

Guideline-Based Recommendations

Diagnosis

• Utilize NGS as the primary method for precision oncology testing.

Management

• Implement automation to streamline NGS workflows and reduce manual steps.

Monitoring & Follow-up

• Continuously assess workflow efficiency and turnaround times.

Risks

• Operational challenges may limit efficiency and scalability of NGS testing.

Patient & Prescribing Data

Patients with solid tumors requiring precision oncology testing.

Precision oncology enables individualized treatment based on NGS results.

Clinical Best Practices

• Achieve an ideal balance of hands-on time and turnaround time.
• Identify and eliminate bottlenecks in NGS workflows.
• Optimize resources to accommodate increasing testing volumes.

References

• Thermo Fisher Scientific Webinar