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The Pathologist / Issues / 2026 / February / Earlier Detection of Organ Rejection
Endocrinology Screening and monitoring Clinical care Liquid biopsy Omics Research and Innovations Molecular Pathology

Earlier Detection of Organ Rejection

CAP review outlines how donor-derived DNA assays can support earlier, less invasive detection of graft injury

02/27/2026 News 1 min read
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Top Institutions in Transplant Medicine and Molecular Diagnostics

Leading institutions utilize advanced molecular techniques such as next-generation sequencing and droplet digital PCR to develop and validate dd-cfDNA assays, integrating these into clinical transplant programs for kidney, heart, liver, and lung transplantation monitoring.

  • #1

    Mayo Clinic

    Rochester, MN

    Mayo Clinic is a leader in transplant research and clinical care, pioneering the clinical application of dd-cfDNA testing in kidney and heart transplantation with extensive validation studies and integration into patient management protocols.

    Key Differentiators

    • Transplant Medicine
    • Molecular Diagnostics
    • Nephrology
    • Cardiology
  • #2

    Massachusetts General Hospital

    Boston, MA

    MGH has contributed significantly to the development of next-generation sequencing techniques for dd-cfDNA and has integrated these assays into heart and kidney transplant surveillance programs.

    Key Differentiators

    • Transplant Surgery
    • Molecular Pathology
    • Cardiology
  • #3

    Stanford University Medical Center

    Stanford, CA

    Stanford has advanced research in dd-cfDNA applications across multiple organ transplants including emerging data in lung and liver transplantation, supported by robust molecular diagnostic platforms.

    Key Differentiators

    • Transplant Immunology
    • Molecular Diagnostics
    • Pulmonology
  • #4

    Johns Hopkins Hospital

    Baltimore, MD

    Johns Hopkins has a long-standing transplant program with active research in molecular diagnostics including dd-cfDNA, focusing on improving early detection of rejection and personalized patient management.

    Key Differentiators

    • Transplant Surgery
    • Molecular Pathology
    • Nephrology
  • #5

    University of California, San Francisco (UCSF) Medical Center

    San Francisco, CA

    UCSF is recognized for its innovative research in molecular diagnostics for transplant rejection, particularly in liver transplantation, and for integrating dd-cfDNA testing into clinical practice.

    Key Differentiators

    • Transplant Medicine
    • Molecular Diagnostics
    • Hepatology

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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