5 Key Takeaways

• 1

  Researchers assembled a complete common marmoset genome, resolving previously missing or incorrectly represented regions.

• 2

  The new genome reference added over 88 million bases of unresolved sequences, improving genomic analysis in disease research.

• 3

  The study identified 21,121 protein-coding genes and 566 new transcript models supported by long-read RNA sequencing.

• 4

  Of 81 human loci associated with Alzheimer's disease, 76 had candidate marmoset counterparts, with coding variation detected in 75.

• 5

  A preliminary marmoset pangenome covering six haplotypes was produced, but it requires further validation for variant discovery.