5 Key Takeaways

• 1

  Non-invasive tests combining liver and spleen stiffness with lab findings may help identify portal hypertension.

• 2

  Clinically significant portal hypertension is defined as a hepatic venous pressure gradient of at least 10 mmHg.

• 3

  HVPG measurement is the reference standard for diagnosing portal hypertension but is limited for routine screening.

• 4

  Adding spleen stiffness measurement can reduce the indeterminate diagnostic range for portal hypertension.

• 5

  AI models show promise in diagnosing portal hypertension but require further validation before clinical use.