Objective:

To compare the spike protein structures of SARS-CoV-2, bat coronavirus RaTG13, and pangolin-CoV to understand the origins of the COVID-19 pandemic.

Approach:

• Comparison of Spike Proteins: Researchers analyzed the spike protein structures of SARS-CoV-2, RaTG13, and pangolin-CoV.

Key Findings:

• The pangolin-CoV spike protein is more similar to RaTG13 than to SARS-CoV-2, except for the receptor-binding domain.
• Pangolin-CoV spike proteins can bind strongly to both human and pangolin ACE2 receptors.
• RaTG13 was unable to bind with either human or pangolin ACE2 receptors.

Interpretation:

Conclusion:

Sources:

• Francis Crick Institute