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Subspecialties Cytology, Biochemistry and molecular biology, Technology and innovation

Understanding the transcriptome of limbal stem cells at the single cell level and their clinical utility in treatment of limbal stem cell deficiency

sponsored by 10x Genomics

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18th of November / 11.00 am CET

Limbal stem cell deficiency (LSCD) is a pathologic condition resulting from dysfunction and/or loss of limbal stem cells (LSCs). In this webinar, I will describe our work in establishing ex vivo expansion of limbal stem cells (LSCs), their transplantation in patients with total/severe unilateral LSCD and single cell analyses which have resulted in identification of a new LSC cell surface marker. Finally, I will describe our recent work in SARS-COv-2 infection of human ocular surface and the cellular response to viral infection, uncovered by the single cell RNA-Seq analyses.

To harness the power of stem cells as therapeutic agents and disease models, you must first understand the fundamentals of stem cell function. Unravelling stem cell diversity and fate requires the ability to identify gene expression profiles, trace cellular lineage, and profile cell subtypes. Biased cellular analysis and pooled samples have constrained stem cell research and contributed to the masking of dynamic cellular events. Single cell and spatial analyses provide novel insight into the molecular mechanisms underlying normal cellular function, differentiation, and disease progression.

Join us for this seminar to learn how Chromium Single Cell and Visium Spatial solutions from 10x Genomics can help you push the boundaries of your stem cell research. Uncover molecular insights, dissect differentiation trajectories, detect novel subtypes and biomarkers, and map the epigenetic landscape at high resolution.

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