Genetic and Transcriptional Contributions to Relapse in Acute Myeloid Leukemia

10/25/2021

For patients with acute myeloid leukemia (AML) treated with chemotherapy, the contribution of genetic heterogeneity to drug resistance and disease progression has been well-established. More recently, studies have begun to investigate the impact of transcriptional heterogeneity to tumor adaptability. However, bulk RNA-sequencing has lacked the resolution to allow the identification of canonical, relapse-associated transcriptional changes. To better understand relapse-associated clonal and transcriptional adaptation, Dr. Allegra Petti and colleagues turned to enhanced whole genome sequencing (eWGS) and ultra-deep single cell RNA-sequencing (scRNA-seq) to examine the correlation between genetic and transcriptional evolution.

Join this webinar, to hear Dr. Petti discuss the findings of this study and learn about:

How integration of eWGS and scRNA-seq enabled quantitative measurement of the co-evolution of genetic and transcriptional heterogeneity and resolved subclone-specific states
Findings indicating that clonal evolution does not represent all relevant biological changes
The identification of leukemic cells seeding resistance

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