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Subspecialties Histology, Oncology, Microscopy and imaging, Clinical care, Training and education

The Heavy Cavalry of Colorectal Cancer

At a Glance

  • Tumor budding is proposed as an additional prognostic factor in the eighth edition of the TNM Classification of Malignant Tumors 2017.
  • As a biomarker of tumor progression, budding is part of the tumor microenvironment and involved in the epithelial-to-mesenchymal transition (EMT).
  • Tumor budding can aid clinical decision-making in early-stage colorectal cancer.
  • A 2016 International Tumor Budding Consensus Conference established a reproducible and cost-effective scoring system.

Personalized healthcare requires solid, reproducible biomarkers to stratify cancer patients into prognostic subgroups. One such factor emerging in colorectal cancer is tumor budding, a novel and promising histopathological biomarker now classified as an additional prognostic factor in the eighth edition of the TNM Classification of Malignant Tumors 2017 (1).

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About the Author

Alessandro Lugli

Professor of Tumor Pathology and Vice-Chair of the Institute of Pathology at the University of Bern, Switzerland

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