Predicting Prognosis in Glioblastoma
The link between cfDNA concentration and progression-free survival for GBM patients
Luke Turner | | Quick Read
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults – and the deadliest. Only five to 10 percent of patients survive longer than five years. Predicting prognosis can be particularly difficult because surgical procedures are complicated and invasive, a challenge exacerbated by the tumor’s heterogeneity. But now, a team from the Abramson Cancer Center of the University of Pennsylvania have found that patients with a higher concentration of circulating free DNA (cfDNA) have shorter progression-free survival. Senior author Erica Carpenter believes this underlines the potential utility of liquid biopsy for monitoring brain tumors.
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