Kill Command for Cancer
What’s the deadliest siRNA sequence?
Luke Turner | | Quick Read
The “cellular kill code” that small interfering RNA (siRNA) molecules harness to eradicate cancer cells has been present for an estimated 800 million years. Unfortunately, we haven’t known what it is or how to use it – until now. The deadly code has now been found to result from just six nucleotides – between positions two and seven in a sequence of 19 – known as the 6mer seed sequence. Marcus Peter, Professor of Cancer Metabolism at Northwestern Medicine, Chicago, USA, led research into the siRNA nucleotide sequence. And he is now understandably excited by the prospect of targeting cancer.
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