Cyto’ the storm
To learn more about the pathogenesis of sepsis, a team has decoded “the cytokine cacophony in sepsis into a pairwise cytokine message capturing the gene, cell and tissue responses of the host to the disease.” Specifically, to understand which molecules controlled organ states in sepsis, the researchers looked at organ gene expression of 6 single recombinant cytokines and 15 pairs of recombinant cytokines. “Strikingly, we find that the pairwise effects of tumor necrosis factor plus interleukin (IL)-18, interferon-gamma or IL-1β suffice to mirror the impact of sepsis across tissues,” write the authors.
Credit: Mycobacterium Tuberculosis Bacteria, the Cause of TB by NIAID / CC BY
The fungus among us
New work has revealed insights into how Aspergillus fumigatus – a fungus that causes infection in thousands of people annually – produces mycotoxin gliotoxin, one of its key metabolites (PMID: 38167253). The team found that the fungus has to attenuate its production of gliotoxin to not negatively affect itself. They also observed that Mitogen-Activated Protein kinase MpkA is crucial for this balance between production and self-preservation. Özgür Bayram, from the international research team, commented, “The newfound knowledge might lay the foundation for a treatment targeting aspergillus infections in patients. Such a breakthrough could have profound implications for individuals undergoing cancer treatments, organ transplants, those with cystic fibrosis, and those managing chronic obstructive pulmonary disease.”
Sitting in the sidelines
New research published in Science Advances has uncovered a mechanism that explains how Mycobacterium tuberculosis (Mtb) is able to lay dormant in the human body for years (PMID: 38091389). The team engineered a version of Mtb without a particular gene that helps the bacteria survive – IscS – and found dramatically reduced virulence in mouse models. The team believe that the IscS gene operates the SUF operon and, when both are depleted, the virulence of Mtb is significantly reduced. The findings could inform future anti-tuberculosis drug development.
Some (don’t) like it hot
Mosquitoes are a globally significant vector for a number of infectious diseases, but models to forecast transmission often assume that their behaviour is similar across populations. A new paper has revealed that heat tolerance is much higher in larvae than in adults, and that tolerance also varies depending on local climate. The annual precipitation of a given area particularly affects the vectors’ tolerance to heat, with greater tolerance observed in wetter regions. This is thought to be due to reduced desiccation of the insects in humid areas.
This time for Africa
New One Health network establishes importance of tackling neglected tropical disease across African continent (PMID: 38172632).
Class of their own
Newly-discovered antibody class capable of neutralising a number of influenza viruses shows potential for vaccine development (PMID: 38127922).
GI No!
Researchers explore how troublesome pathology of GI tract infections can lead to actionable diagnoses (PMID: 37863566).
Bacteria bonanza
The University of Basel discovers over 30 species of novel bacteria in patient samples – many belonging to either Corynebacterium and Schaalia genera (PMID: 38178003).
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