Subscribe to Newsletter
Subspecialties COVID-19, Genetics and epigenetics, Microscopy and imaging

Coronaviruses and the Common Cold: N Protein Comparisons

“The structures show the comparisons between N protein models for pandemic-related coronaviruses – SARS-CoV-2 (red), Civet (orange), SARS-CoV (tan), MERS (pink) – and common-cold coronaviruses – OC43 (yellow), HKU1 (blue), NL63 (gray), 229E (cyan). For the sequence alignments, our paper (1) defined a new region (~15 amino acids) in the N protein of SARS-CoV-2 where patient antibodies interact. This sequence is 100 percent conserved in all documented patient samples and variants to date. It is also nearly identical in SARS-CoV and Civets. Larger variability is shown in MERS.”

 – Deborah F. Kelly, Professor of Biomedical Engineering and Director of the Center for Structural Oncology at Penn State University.

Receive content, products, events as well as relevant industry updates from The Pathologist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. MA Casasanta et al., Nanoscale, 13, 7285 (2021). PMID: 33889923.
Register to The Pathologist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Pathologist magazine