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Subspecialties Clinical care, Histology

Case of the Month

This gastric biopsy was taken from an asymptomatic 30-year-old woman with a familial history of hereditary diffuse gastric carcinoma. Slide A was stained with hematoxylin and eosin, and slide B was stained immunohistochemically with the antibody to cytokeratin CK7.

Mutation of which gene most likely accounts for the pathologic changes seen in this biopsy?

A. CDH1 


C. STK11



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We will reveal the answer in next month’s issue!

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Answer to last issue’s Case of the Month…

Histiocytic necrotizing lymphadenitis (of Kikuchi and Fujimoto) is a self-limiting, well-defined clinicopathologic disorder of unknown etiology. Microscopically, the lymph node architecture is partially effaced with dormant, non-hyperplastic follicles. Characteristic histologic findings include eosinophilic amorphous material, abundant karyorrhectic debris and viable cells. Absence of vasculitis is a clue to exclude a diagnosis of systemic lupus erythematosus. In cases such as this, clinical, serologic and pathologic correlation is crucial to arrive at a  correct diagnosis.

Submitted by Seshadri Thirumala, Director of Surgical Pathology, Ameripath Lubbock, USA

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