This gastric biopsy was taken from an asymptomatic 30-year-old woman with a familial history of hereditary diffuse gastric carcinoma. Slide A was stained with hematoxylin and eosin, and slide B was stained immunohistochemically with the antibody to cytokeratin CK7. Mutation of which gene most likely accounts for the pathologic changes seen in this biopsy? A. CDH1 B. CTNNA1 C. STK11 D. RET E. FOXL2
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Answer to last issue’s Case of the Month… Histiocytic necrotizing lymphadenitis (of Kikuchi and Fujimoto) is a self-limiting, well-defined clinicopathologic disorder of unknown etiology. Microscopically, the lymph node architecture is partially effaced with dormant, non-hyperplastic follicles. Characteristic histologic findings include eosinophilic amorphous material, abundant karyorrhectic debris and viable cells. Absence of vasculitis is a clue to exclude a diagnosis of systemic lupus erythematosus. In cases such as this, clinical, serologic and pathologic correlation is crucial to arrive at a correct diagnosis. Submitted by Seshadri Thirumala, Director of Surgical Pathology, Ameripath Lubbock, USA
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