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Subspecialties Histology

Case of the Month

A 42-year-old female presented with a painful, slowly growing nodule on her hand. The histopathology is shown below (Figures 1-4).

Given the morphologic findings, what is the most appropriate diagnosis?

A.  Chondroid syringoma
B.  Glomus tumor
C.  Eccrine hidradenoma
D.  Myopericytoma
E.  Mucinous carcinoma

Submitted by Muhammad Ahsan, Chughtai Institute of Pathology, Lahore, Pakistan, and Rida Noor, Faisalabad Medical University, Faisalabad, Pakistan.

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Answer to July/August's Case of the Month

D. Treatment for dysphonia a decade prior to biopsy

The laryngeal biopsy shows abundant polarizable crystalloid structures with associated granulomatous inflammation and foreign-body giant cells. This patient had a long-standing history of dysphonia and had undergone treatment with intralaryngeal Teflon injection ten years prior to biopsy. Historically used in the treatment of unilateral vocal cord paralysis, intralaryngeal Teflon injection has fallen out of favor due to frequent complications, including the exuberant granulomatous response illustrated by this case. This condition is known as a "Teflon granuloma.”

Submitted by Megan C. Smith, Resident in Anatomic and Clinical Pathology, Vanderbilt University Medical Center, Department of Pathology, Microbiology, and Immunology, Nashville, TN, USA.

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  1. Goodman TF. Fine structure of the cells of the Suquet-Hoyer canal. J Invest Dermatol. 1972;59(5):363-369. doi:10.1111/1523-1747.ep12627480
  2. Gombos Z, Zhang PJ. Glomus tumor. Arch Pathol Lab Med. 2008;132(9):1448-1452. doi:10.5858/2008-132-1448-GT
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