A Closer Look at Chimerism
For the first time, researchers reveal the molecular mechanisms behind chimeric transplant tolerance
Michael Schubert |
A vital organ transplant may seem like the end of a long journey through illness, treatment, and weeks, months, or years of waiting. But, in many cases, a new organ is only the beginning of another lifelong journey of immunosuppression and the constant risk of rejection. The immediate concern after transplant is to avoid acute rejection, a condition that places both the patient and the graft at risk. And though immunosuppressive therapy is an effective treatment for acute rejection, it carries its own set of disadvantages, including nephrotoxicity and the risk of opportunistic infections. What can be done to balance these two competing interests?
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