The Trials of Mesothelioma
The International Mesothelioma Interest Group has issued updated guidelines for diagnosis
Famously linked to asbestos exposure, malignant mesothelioma (MM) is an uncommon cancer that can prove difficult to accurately diagnose. But as testing methods advance, methods for distinguishing subtypes of MM are improving – with newer antibodies becoming available for immunohistochemistry (IHC) panels, and molecular testing methods displacing IHC in some cases as the preferred method for separating benign and malignant proliferations.
To provide guidance for pathologists and address the latest advances, the International Mesothelioma Interest Group has issued updated guidelines, covering a range of practical topics for pathologists looking to accurately diagnose MM (see Table 1), while also covering some of the latest advances, including predictors of prognosis and therapy response (1).
The authors caution that pathologists should not consider asbestos exposure when diagnosing the disease, but offer a notable reminder: “MM, although a rare tumor, has a grave prognosis and invariably has medicolegal implications.”
- AN Husain et al., “Guidelines for pathologic diagnosis of malignant mesothelioma: 2017 update of the consensus statement from the international mesothelioma interest group”, Arch Pathol Lab Med, [Epub ahead of print] (2017). PMID: 28686500.
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