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The Pathologist / Issues / 2022 / Mar / The Art of the Laboratory
Histology Profession Histology Microscopy and imaging Professional Development

The Art of the Laboratory

For the seventh time, we asked you to share the images you think capture the most beautiful, educational, or amusing aspects of pathology – and you delivered. Welcome to our gallery tour of the most visually striking discipline in medicine!

03/25/2022 Gallery 1 min read

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Alicia Rumayor Piña

Credit: Alicia Rumayor Piña, Dentistry School, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico.

A Perfect Swirl
Keratin pearl in a tongue squamous cell carcinoma.

Snake Vessel
Adipose tissue and a snake-shaped blood vessel.

Amber Matkowski

Credit: Amber Matkowski, Junior Doctor, Wye Valley NHS Trust, UK.

Another World
Digital manipulation of amyloid deposits visualized by polarized light microscopy.

Ana I. Hernandez Caballero

Credit: Ana I. Hernandez Caballero, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA

Colon Flowers
Kreyberg stain of a colon biopsy.

Squamous Seahorse
H&E stain of an esophageal biopsy.

B. Alan Rampy

Credit: B. Alan Rampy, Associate Professor of Diagnostic Medicine and Medical Education and Distinguished Teaching Professor, The University of Texas at Austin, Texas, USA.

Mucineon
A stylized example of histopathology from a mucinous cholangiocarcinoma.

Caroline Stanek

Credit: Caroline Stanek, PGY-1, Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Alabama, USA

XOXO Biopsy
A tubular adenoma from a GI biopsy.

Christine Carreira

Credit: Christine Carreira, Research Assistant, WHO/IARC Classification of Tumours Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

T. rex
Human cervical biopsy CIN3.

Phoenix
Human cervical biopsy CIN3.

Cooper Schwartz

Credit: Cooper Schwartz, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Crypto Mushroom
A collage of slides of lung tissue from a patient with disseminated Cryptococcus neoformans fungal infection.

Dalila Villalobos

Credit: Dalila Villalobos, PGY-5 Anatomical Pathology, Queen's University, Kingston, Ontario, Canada

Gouty Rain
A needle-shape negative birefringent image of gout.

Emanuela Veras

Credit: Emanuela Veras, Highlands Pathology, Bristol, Tennessee, USA.

Fasciola Hepatica Tree
Pathology images are often reminiscent of real-life objects, animals, and many other things we frequently find in our daily surroundings. I am inspired by what I see under the microscope to create a connection between these two worlds.

Sessile Serrated Adenoma Ocean

Curious Giardia

Twisted Taenia

Franz Jobert L. Sebastian

Credit: Franz Jobert L. Sebastian, Philippine Heart Center, Quezon City, Philippines.

The Invasion Begins
A long time ago in a galaxy far, far away... a galactic strike ship from an unknown planet is ready to invade and conquer the universe. This photomicrograph is a mitral valve from a patient with rheumatic heart disease with amyloid accumulation, stained with Congo red to show the characteristic apple-green birefringence on a polarizing microscope.

Frazer Bell

Credit: Frazer Bell, Histopathology Technician, Veterinary Diagnostic Services, University of Glasgow, Scotland, UK

Peer Inside the Fish
Longitudinal cross section of fish fry stained using Masson’s trichrome protocol. By Frazer Bell, Lynn Stevenson, Lynn Oxford, and Jan Duncan.

Medusa Fish Gills
Fish gills looking like jellyfish during the medusa phase, stained using Masson’s trichrome protocol. By Frazer Bell, Lynn Stevenson, Lynn Oxford, and Jan Duncan.

Stained Glass Fish Spine
A magnified look into the spine of a fish, looking almost like a stained glass window. By Frazer Bell, Lynn Stevenson, Lynn Oxford, and Jan Duncan.

Angie Rupp

Credit: Angie Rupp, Senior Veterinary Clinician, Veterinary Diagnostic Services, University of Glasgow, Scotland, UK

Walking the Cobblestones of OPA
Ovine lung stained using IHC pan-cytokeratin. Ovine pulmonary adenocarcinoma (OPA) caused by jaagsiekte sheep rotavirus (JSRV). By Angie Rupp, Frazer Bell, Lynn Stevenson, Lynn Oxford, and Jan Duncan.

Gabriel Arismendi-Morillo

Credit: Gabriel Arismendi-Morillo, Pathologist, Professor, and Researcher, Electron Microscopy Laboratory, Biological Researches Institute, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela.

Malevolent Clown
Picture from a surgical piece with breast ductal carcinoma. (Histology technicians: G. Arteaga and P. Arteaga.)

Supernova
Picture from a chest tumor: pleomorphic liposarcoma. (Histology technicians: G. Arteaga and P. Arteaga.)

Helix Nebula: "The Eye of God"
Picture from a brain tumor: pleomorphic xanthoastrocytoma. (Histology technicians: G. Arteaga and P. Arteaga.)

Mercia Locke

Credit: Mercia Locke, Cytotechnologist, Southern Arizona VA Health Care System, Tucson, Arizona, USA

0322-401-Mercia-Locke-2.png

Lazy Goat
When you're trying to screen slides, but pareidolia takes over...

Georgios Kitsakis

Credit: Georgios Kitsakis, Histopathology Resident, General Hospital of Volos, Greece.

Goofy Smile
Fetal tissue.

Hansini Laharwani

Credit: Hansini Laharwani, PGY-4 Pathology Resident, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Deep Purple
A polarized image of feces under a microscope.

Inny Busmanis

Credit: Inny Busmanis, Senior Consultant Pathologist, Singapore General Hospital, Singapore.

Message From the Heart
An incidental finding from an affectionate specimen. Taken using the InfinityCapture system.

Jagmohan S. Sidhu

Credit: Jagmohan S. Sidhu, Medical Director and Chairman, Department of Pathology and Laboratory Medicine, United Health Services Hospitals-Wilson Medical Center/ Binghamton General Hospital, Johnson City/Binghamton, New York, USA.

A histologic section of a skin biopsy specimen looks like an eagle with a hair follicle looking like its eye.

A histologic section of a normal skin biopsy specimen looks like a Parrot.

A histologic section of a small piece of decidual tissue in an endometrial curettage specimen looks like a lady praying in a prostrate position.

A histologic section of a cell-block of a fine needle aspirate of a mediastinal lymph node shows a cluster of metastatic squamous cell carcinoma cells that looks like a dog.

James Lewis, Jr.

Credit: James Lewis, Jr., Professor and Chief of Head and Neck and Endocrine Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Rolling Eyes
A most sarcastic oncocytic papilloma!

Jason Innerhofer

Credit: Jason Innerhofer, Lead Pathologists’ Assistant; Faculty Preceptor, Rosalind Franklin University; and Clinical Instructor, University of New Mexico, Albuquerque, New Mexico, USA.

Nature's Gallbladder
Pathology is in the eye of the beholder…

Jayashree Kulkarni

Credit: Jayashree Kulkarni, Consultant and Head of Hematopathology, Sri Shankara Cancer Hospital and Research Center, Bangalore, India.

E-Rosette Bouquet
Cerebrospinal fluid light microscopy showing erythrocytes rosetting around lymphocytes and neutrophils. The bouquet was made using a grid art app.

José Antonio Ortiz Rey

Credit: José Antonio Ortiz Rey, Hospital Álvaro Cunqueiro, Vigo, Spain.

Astonished
The Astonished Prostate Adenocarcinoma

Maaia Jentus

Credit: Maaia Jentus, Medical University of Vienna, Austria

These Are Pathologists
People who have met me know that medicine is my biggest passion – a fire that burned even brighter when I met my pathology squad. It’s about the beauty of nature and mechanisms. About asking not “why?” but “how?” About endless hours spent sitting at a microscope, with whole-slide images on a screen, in the lab, in dissection rooms, listening to lectures and congresses… And now, I also help to improve pathology teaching. Curiosity makes science fun.
In 2017, I began thinking about future imaging possibilities. These colleagues are sitting around a table with a 3D holographic biopsy/MRI molecular image…

The Bond of Love
This art was a recent commission for a kidney pathologists as a present from his cardiologist wife.

Yeonsoo Sara Lee

Credit: Yeonsoo Sara Lee, Resident, Department of Pathology, LAC+USC Medical Center, Los Angeles, California, USA

BM CD34 & BM H&E
These pieces were created for a mentor of mine who is a pathologist. They are inspired by CD34 and H&E stains of bone marrow; the medium is watercolor, metallic paints, and ink. Though I am still open to the specialty I will be pursuing, I have a particular fondness for pathology and laboratory-based medicine. I was a field ecologist in a previous life (as a nontraditional medical student) and spent much time peering through scopes at different freshwater microorganisms. Disease ecology is eventually what brought me to medicine, so I am grateful for my time in the lab.

Mayah Hijazi

Credit: Mayah Hijazi, Resident, Department of Pathology, LAC+USC Medical Center, Los Angeles, California, USA

Corporae
Gorgeous concentric circles in a corpus amylaceous. In reality, this would be a sphere; let your imagination run wild to this artistry in life.

Michael J. Klein

Credit: Michael J. Klein, Professor of Pathology and Laboratory Medicine at Weill-Cornell College of Medicine and Pathologist in Chief Emeritus at the Hospital for Special Surgery, New York, USA

0322-401-Michael-Klein-1.png

Pandemic Paintings
At the Hospital for Special Surgery, we were lucky enough to be able to use whole-slide imager (with FDA approval) to do at least some of our signout work from home.

Nonetheless, the pandemic definitely increased my reading time and my bread-baking skills. For me, however, a return to painting watercolors after a 40-year break has been a good distraction.

I am not too good at artwork, but I have learned enough to know that, when interpersonal contact comes back and I’m less paranoid about getting a breakthrough case, I’m going to invest in lessons from someone who knows how to paint a bit better than I do!

Nika Gloyeske

Credit: Nika Gloyeske, Clinical Assistant Professor, Pathology and Laboratory Medicine, The University of Kansas Health System, Kansas City, Kansas, USA

Star Mit, Star Bright
A uniquely shaped mitosis in a triple-negative breast cancer.

Nusaiba Alrefae

Credit: Nusaiba Alrefae, Cytopathology Unit, Sabah Hospital, Kuwait

Flying Bird
An image taken from ThinPrep preparation of a fine needle aspiration biopsy of a thyroid nodule.

Richard Prayson

Credit: Richard Prayson, Cleveland Clinic, Cleveland, Ohio, USA.

The Psammomatous Night
Psammomatous meningioma in the background sky of Vincent van Gogh’s Starry Night.

Sadaf Sarfraz

Credit: Sadaf Sarfraz, Molecular Pathology and Genomics, Forman Christian College University, Lahore, Pakistan.

Contentment
A collection of paintings by cancer researcher Sadaf Sarfraz.

Companion

Fierce Flight

Sanjay A. Pai

Credit: Sanjay A. Pai, Consultant Pathologist and Head of Pathology, Manipal Hospital Yeshwanthpur, Bangalore, India.

Xenotransplant
This image of a prostatic gland has an uncanny resemblance to Lord Ganesha in Hindu religion and mythology. Note that Lord Ganesh often has a rat near his feet – and even that is depicted in this prostate!

Sheryl Lammers

Credit: Sheryl Lammers, Retired Medical Technologist, Metropolitan Medical Laboratory, Moline, Illinois, USA

Invasive
Watercolor and ink.

Supriya R. Donthamsetty

Credit: Supriya R. Donthamsetty, Ochsner Medical Center, New Orleans, Louisiana, USA.

Road to Mama
A young woman is walking along a road and looking back with uncertainty. The end of the road turns into an umbilical cord and ends in a placenta. The placenta symbolizes motherhood; the road the connection of the young woman with her mother. It is uncertain why this young woman is seeking connection with her mother at this particular time in her life.

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