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Outside the Lab Histology, Clinical care

Case of the Month

A 55-year-old woman presented with a vulvar lesion that was biopsied. The malignant cells with clear cytoplasm were negative for melanoma markers, but reacted with an antibody to one of the cytokeratins. Which antibody most likely reacted with these tumor cells?.

Antibody to…

a Cytokeratin CK1
b Cytokeratin CK7
c Cytokeratin CK5/6
d Cytokeratin CK20

Click to register your guess

We will reveal the answer in next month’s issue!

Do you think you have a good case of the month? Email it to [email protected]

Answer to last issue’s Case of the Month…

C. Medullary carcinoma

Renal medullary carcinoma is a rare tumor, predominantly found in young men and women of African origin who carry the sickle cell trait. In the microphotograph selected to illustrate the current case, two patterns can be seen: a reticular pattern resembling yolk sac tumors and a nondescript solid pattern. Several other patterns – such as papillary, tubular, or cribriform – may coexist in these tumors, which are known for their characteristic loss of nuclear SMARCB1 (INI-1) protein (1).

1. C Ohe et al., “Reappraisal of morphologic differences between renal medullary carcinoma, collecting duct carcinoma, and fumarate hydratasedeficient renal cell carcinoma”, Am J Surg Pathol, 42, 279–292 (2018). PMID: 29309300.

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