Research published in Nature Aging reveals that progerin is present in 82 percent of arteries from chronic kidney disease (CKD) patients, with variation up to 21 percent in vascular smooth muscle cells. The study evaluated the occurrence of the LMNA c.1824C>T variant as a somatic event in calcified arteries from CKD patients undergoing renal transplantation. Progerin frequency correlated with disease duration and DNA damage markers. Additionally, findings indicated increased endoplasmic reticulum stress in progerin-positive cells, implicating these features in early vascular aging associated with CKD.
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